The level of receptors expressed on the cell surface determines the cellular responsiveness to agonists. Proteinase-activated receptors (PARs) have been reported to be either upregulated or down-regulated in response to various types of stimulation and pathological situations. In addition. the transcriptional regulation plays a major role in the alteration of the expression of PARs un... https://www.roneverhart.com/Belle-de-Grasse-Eau-de-Toilette/